Tablets
In this application, gelatine is used for its binding properties and brings cohesiveness and resistance, hardness to the tablet.
More often, gelifying gelatines are used after wet granulation of the powder to be used in compression, while hydrolyzed gelatines can be used also in direct compression.
In wet granulation, gelatine is used at 5 to 10 % in warm aqueous solutions to avoid gelation.
Standard gelatines have a higher binding power compared to hydrolyzed collagen and, above all, a higher final cohesive power. The cohesiveness, the hardness of granules or tablets are enhanced, combined with a longer disintegration time.
The dissolution of the table will depend on the type of gelatines used: the higher the gel strength, the longer the dissolution time, but the higher the physical properties (cohesiveness…).
If suited, a reticulation step can be added during the wet granulation process to improve mechanical resistance of the granules or to obtain lower water solubility.