药物递送：利用明胶和胶原蛋白肽的优势和多功能性
明胶已在许多先进的药物递送系统中显示出强大的实用性和多功能性。例如（生物制剂的）大分子和小分子在微球和纳米球中的封装、凝胶薄膜、眼用膜剂和滴眼液等。在所有这些应用中，明胶在控制多种不同化学物质（疏水性、亲水性或中性）的药物释放方面提供了极大的灵活性。即使生物利用度低的药物也已成功使用明胶进行配伍生产 (Nikkhah 等人，2016 年)。
1.Young S. 等人。2005 年。明胶作为生物活性分子控制释放的递送工具。Journal of controlled release: official journal of the Controlled Release Society 2005, 109 (1-3), 256-74.
2.Elzoghby A. O. 2013 年。作为药物和基因递送系统的明胶基纳米微粒：回顾三十年的研究。Journal of controlled release: official journal of the Controlled Release Society 2013, 172 (3), 1075-91。
Rousselot – your expert partner for biodelivery solutions
Our experienced team will recommend an optimal medical grade gelatin or modified gelatin for your specific drug delivery application, customizing a tailored solution to support drug development from formulation to the most advanced delivery, with high purity, quality and consistency.
Applications of X-Pure® gelatin in bio delivery
Customizable gelatin for microneedle applications
X-Pure® supports uniform patch fabrication and scalable production.
Purified gelatin for drug delivery implants (in body)
X-Pure® can be tailored to achieve the optimal level of controlled or sustained release, texture, dose & desired pharmacokinetics parameters.
Purified gelatins for vaccines
Rousselot hydrolyzed gelatins help to stabilize vaccines while minimizing the risk of endotoxin-induced immune responses.
Micro- and submicro- particle applications
X-Pure® gelatins can be shaped into different structures to support specific, targeted and controlled release.
Why is gelatin an ideal delivery vehicle for biomolecules?
- Excellent biodegradability: Gelatin is a protein derived from collagen. It is naturally degraded by enzymes in the body (metalloproteinases).
- No immune response: Gelatin is safe and does not stimulate an immune response in the body.
- Compatible with multiple APIs: Gelatin protects the cell membrane and stabilises proteins. It is therefore compatible with many different APIs, RNA, DNA, cells and biologics.
- Versatility: Gelatin can be shaped into different structures to support specific, targeted and controlled release for a wide range of delivery methods, including large and small molecules encapsulated in micro and nano-spheres, gel films, colloidal injectables, ocular inserts, eyedrops, microneedles and implants. 1
- Tunable release: By forming complexes with different drugs and tuning parameters, including degree of crosslinking and molecular weight, it is possible to optimize gelatin’s degradation and drug delivery kinetics.
How can Rousselot help you optimize drug or cell delivery?
Our experienced team can help you maximize the potential of gelatin-based biomaterials and design highly accurate and precise delivery systems.
1. Ultra-low endotoxins to support patient safety
Endotoxins can cause significant adverse effects in drug delivery applications.2 To overcome this problem, Rousselot’s X-Pure® range is ultra-purified and has been developed to ensure maximum quality and safety.3
2. Customizable for precise and efficient drug or cell delivery
Rousselot can help you select the gelatin with the right mechanical properties to ensure optimal spatio-temporal control. With tunable properties including consistency, adhesiveness and biodegradability, X-Pure® gelatins enable you to achieve precise timing and targeted short term or sustained release of drugs or cells within the body.
Modified gelatin designed for drug delivery: X-Pure® gelatins can be modified (or functionalized) to bind, carry, and deliver drugs to targeted sites in the body, enhancing their therapeutic efficacy and reducing potential side effects.
Gelatin with tunable mechanical properties for cell delivery: X-Pure® gelatins have customizable mechanical properties to recreate an environment that mimics the cell’s natural extracellular matrix for successful cell culture. By tuning the molecular weight and level of crosslinking, X-Pure's biodegradability can be tuned to meet your delivery targets.
Figure 1: Different cells require different environments.
3. Compliance
All X-Pure® and Quali-Pure® gelatins are compliant with the requirements of the major pharmacopoeia and support regulatory compliance with the EU Medical Device Regulation (MDR) 2017/745 and US FDA guidance for medical devices. Our biomaterials come with full traceability, readily available documentation and validated viral inactivation as also required by ISO 22442, helping to save time when reaching the clinic.