Peptan products score high on bioavailability

To ensure excellent bioactivity, it is essential for collagen to reach the target tissues as efficiently as possible, to be highly bioavailable. Peptan is easily digested and excellently absorbed. Small Peptan-derived peptides reach the blood stream within one hour after intake. From the blood the peptides (containing hydroxyproline, a unique amino acid) are transported into the target tissues, e.g. skin, bones and cartilage, where they deliver a signal to the local cells and help the cell to improve its function. This functional adaptation is at the heart of the health benefit that the consumer experiences. 

Excellent digestibility + efficient absorption = high bioavailability

In a model [1] imitating digestion in the human gastro-intestinal tract, Peptan of different raw material origin, P (porcine), B (bovine) and F (fish), were tested for their digestibility. All Peptans were equally well digested into with a molecular weight below 2000 Dalton, a size that allows easy absorption by the intestine. In an in vivo study[2], the appearance of free and peptide-bound hydroxyproline was measured in the blood at different time points over 24h after ingestion of Peptan. Peptan was quickly absorbed with an absorption peak at 0.5 to 1 hour after ingestion of the product.

A new study has presented pioneering scientific evidence of Peptan’s high bioavailability in humans.[3] Targeted analysis of serum drawn after Peptan intake showed increased levels of hydroxyproline-carrying dipeptides, well-known in scientific literature as markers for collagen bioavailability and described to carry bioactivity.

Findings from this study revealed:

  • Collagen peptides from different animal sources become more similar when the average molecular weight drops along the digestion and the absorption process
  • Relevant bioactive peptides are formed during the ingestion of Peptan

Peptan’s high bioavailability

 

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[1] Rousselot data, 2007

[2] Wauquier F. et al., 2019, Human enriched serum following hydrolysed collagen absorption modulates bone cell activity: from bedside to bench and vice versa, Nutrients, 2019, vol. 11, no. 6, pg. 1249.

[3]Kleinnijenhuis, A.J., 2019. Non-targeted and targeted analysis of collagen hydrolysates during the course of digestion and absorption. Anal Bioanal Chem. 2019 Dec 24. doi: 10.1007/s00216-019-02323-x.