Joint Health

Collagen is the key structural component of cartilage tissue and maintaining intact cartilage is essential to maintain healthy and flexible joints. The efficacy of Peptan collagen peptides and the mechanism behind its ability to support and improve joint function and joint comfort is backed by scientific studies.

Maintaining healthy joints

In a randomized, placebo-controlled, double-blind clinical trial1, 94 women aged 40-70 with knee joint problems (osteoarthritis classification: 0-III) received 8g of Peptan or placebo daily for a period of 6 months. 

  • The WOMAC score is the international standard method for assessing joint health clinically in patients

  • Peptan treatment resulted in a statistically significant reduction in the WOMAC score by a -22% linked to a 32% decrease in joint pain and 44% improvement of stiffness (subscale scores).

Improving joint function

The same study also sought to discover whether Peptan could improve knee joint function in the same group of women.

  • The Lysholm score is linked to improved knee movement in everyday activities,
  • Peptan treatment resulted in a statistically significant increase of the Lysholm score by 7% which demonstrates the improvements over time.    


Stimulating chondrocytes (cartilage cells)

In an in vitro study2, primary cartilage cells (chondrocytes) were cultured in the presence of different concentrations of Peptan for 8 days to demonstrate Peptan’s ability to induce the production of the key cartilage components, aggrecan and type 2 collagen, which make up joint tissue.

  • Peptan treatment clearly stimulated the expression of aggrecan and type 2 collagen by the joint cells.

Cartilage protection and anti-inflammatory effects of Peptan

A recent in vivo study3 confirms Peptan's role in supporting joint health, providing scientific documentation of the mechanisms behind cartilage maintenance and joint inflammation reduction.

  • Preserves cartilage area during osteoarthritis development
  • Stimulates chondrocyte proliferation (increased number) and stimulates proteoglycan synthesis.
  • Normalizes synovial thickness and reduces production of the inflammatory marker TNF.

Find out more details about this study

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Peptan IIm's joint health benefits backed by science

Extracted from natural sources, Peptan IIm is a unique hydrolyzed cartilage matrix that contains hydrolyzed collagen Type II in the form of bioactive peptides and glycosaminoglycans - chondroitin sulfate and hyaluronic acid, helping protecting healthy cartilage from degeneration. In a recent in vivo study4, Peptan IIm has been demonstrated to be effective at a low dose: 

  • In post-traumatic osteoarthritis
    • Protects the cartilage from degeneration and promotes lubrication
    • Anti-inflammatory action in the knee joint (local inflammation) 
  • In post-traumatic osteoarthritis of obesity 
    • Protects the cartilage from degeneration and promotes lubrication
    • Anti-inflammatory action in the knee joint (local inflammation)

Peptan IIm has a high absorption rate, indicated by high levels of hydroxyproline after one hour of feeding of the animal model in the same study.


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