Bones are living tissues which undergo remodeling, a process which is important to ensure healthy bone mass density and avoid fractures throughout our lives. Collagen provides the organic framework in bones on which minerals are deposited; it also contributes to bone flexibility and strength.
Calcium, vitamin D and protein are the key bone health nutrients. As a pure protein, Peptan collagen peptides work together with calcium and vitamin to support bone health.
As documented in in vitro, and in vivo studies1,2,3,4, supplements with Peptan collagen peptides exerts bioactivity that helps bone to stay strong and healthy.
Peptan Research has shown that collagen peptides can stimulate the endogenous production of collagen in bone tissue, triggering osteoblasts (bone formation cells) and increasing bone size and firmness4. In another study conducted in 2019, Peptan has been shown to positively affect the balance of bone breakdown and bone formation5. This results in an increase in bone mass and thus in stronger bones.
In an in vivo study4, an established model that mimics the loss of bone mass in postmenopausal women (Ovx) was used to investigate the effect of Peptan supplementation. The experimental group (Ovx + Peptan) received a daily dose of Peptan for 3 months in addition to a normal diet (with adequate level of calcium, protein and Vitamin D). The Ovx and Control group received a normal diet only.
The study found that the group taking Peptan maintained the same mineral density (BMD) level as the non-ovariectomized mice over the test period. In contrast, the ovariectomized mices experienced a reduced BMD.
The same study as above also investigated the microarchitecture and strength of the bones and demonstrated the following:
- Peptan treatment increases ultimate bone strength compared to the control group.
The mechanisms behind Peptan’s bone health benefits are well known. As an example, Peptan was compared to a control protein in the in vitro study4, referred to below, primary bone cells were cultured in the presence of Peptan for 2 weeks.
- Peptan treatment promoted the formation of bone-forming cells (osteoblasts) and stimulated their activity. In contrast, the presence of bone-resorbing cells (osteoclasts) was suppressed. The control protein (BSA) did not show the same effect.
In our recently published in vivo study on bone metabolism5, performed in a collaboration with INRA in France, Peptan was shown to stimulate processes involved in forming bone mass and inhibited the formation of fully functional cells that break down bone mass. Peptans of different raw material origin (bovine, porcine, fish) all showed comparable benefits. Those findings clearly demonstrate that Peptan collagen peptides work on both sides of the balance – improving bone formation, reducing bone breakdown – to improve overall bone health.
5. Wauquier F. et al., 2019, Human enriched serum following hydrolysed collagen absorption modulates bone cell activity: from bedside to bench and vice versa, Nutrients, 2019, vol. 11, no. 6, pg. 1249.
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