Gelatin has demonstrated great utility and versatility in many advanced drug delivery systems. Examples include large and small molecules (biologics) encapsulated in micro- and nano-spheres, gel films, ocular inserts, and eye drops. In all of these applications, gelatin offers great flexibility in the control of drug release across a wide range of chemistries (hydrophobic, hydrophilic, or neutral). Drugs that have struggled from poor bio-availability have been successfully formulated with gelatin (Nikkhah, et al., 2016).
Gelatin-based micro and submicron particles: a growing use in the field of biomolecule- and drug delivery and regenerative medicine
Recently, gelatin based micro- and submicron particles, have gained interest in the field of biomolecule- and drug delivery and regenerative medicine1-2. Endotoxins are important for these applications. Any remaining endotoxin may cause significant adverse immunogenic effects. X-Pure is ultrapure, low in endotoxin and without compromise in the unique tunable and biocompatible characteristics of natural gelatin. With X-Pure, it is now possible to prepare gelatin micro/submicron particles and colloidal injectable gels complying with the highest regulation and quality standards for biomolecule- and drug delivery and regenerative medicine.
1. Young S. et al. 2005. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. Journal of controlled release: official journal of the Controlled Release Society 2005, 109 (1-3), 256-74.
2. Elzoghby A. O. 2013. Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research. Journal of controlled release: official journal of the Controlled Release Society 2013, 172 (3), 1075-91.